{"id":4205,"date":"2019-05-19T10:01:39","date_gmt":"2019-05-19T07:01:39","guid":{"rendered":"https:\/\/mereusanatosi.ro\/wp\/?p=4205"},"modified":"2019-05-19T10:01:41","modified_gmt":"2019-05-19T07:01:41","slug":"o-noua-strategie-terapeutica-pentru-leucemia-mieloida-acuta","status":"publish","type":"post","link":"https:\/\/mereusanatosi.ro\/wp\/2019\/05\/19\/o-noua-strategie-terapeutica-pentru-leucemia-mieloida-acuta\/","title":{"rendered":"O nou\u0103 strategie terapeutic\u0103 pentru leucemia mieloid\u0103 acut\u0103"},"content":{"rendered":"\n<figure class=\"wp-block-image\"><img loading=\"lazy\" width=\"800\" height=\"445\" src=\"https:\/\/mereusanatosi.ro\/wp\/wp-content\/uploads\/2019\/05\/leucemia-mieloida-acuta-800x445.jpg\" alt=\"\" class=\"wp-image-4206\" srcset=\"https:\/\/mereusanatosi.ro\/wp\/wp-content\/uploads\/2019\/05\/leucemia-mieloida-acuta-800x445.jpg 800w, https:\/\/mereusanatosi.ro\/wp\/wp-content\/uploads\/2019\/05\/leucemia-mieloida-acuta-300x167.jpg 300w, https:\/\/mereusanatosi.ro\/wp\/wp-content\/uploads\/2019\/05\/leucemia-mieloida-acuta-768x427.jpg 768w, https:\/\/mereusanatosi.ro\/wp\/wp-content\/uploads\/2019\/05\/leucemia-mieloida-acuta.jpg 1067w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><figcaption>Surs\u0103 foto: https:\/\/www.thehealthsite.com<\/figcaption><\/figure>\n\n\n\n<p>Cercet\u0103torii de la\nInstitutul Ludwig Boltzmann din Viena au identificat o nou\u0103 strategie\nterapeutic\u0103 pentru leucemia mieloid\u0103 acut\u0103 (AML), cea mai comun\u0103 form\u0103 a\nacestei afec\u021biuni. Ei au descoperit c\u0103 activitatea proteinei oncogene C\/EBP\u03b1\nmutante este dependent\u0103 de un adjuvant epigenetic func\u021bional, complexul MLL1\nhiston\u0103 metiltransferaz\u0103. Testele de laborator au ar\u0103tat c\u0103 perturbarea fun\u021bional\u0103\na complexului MLL1 a dus la moartea celulelor AML cu muta\u021bii C \/ EBP\u03b1. \u00cen plus,\ntratamentul cu inhibitor a eliberat blocul de diferen\u021biere al celulelor\ncanceroase \u0219i a restabilit maturarea normal\u0103 a celulelor sanguine. <\/p>\n\n\n\n<p>Potrivit rezultatelor\npublicate recent, interac\u021biunea proteinei mutante cu un regulator epigenetic,\na\u0219a-numitul complex MLL1, reprezint\u0103 o vulnerabilitate specific\u0103 a celulelor\nAML cu muta\u021bii CEBPA. S-a constatat c\u0103 dac\u0103 complexul MLL1 a fost inhibat\nfunc\u021bional, celulele AML au murit. <\/p>\n\n\n\n<p>&#8220;La pacien\u021bii\ncu AML, cele mai multe muta\u021bii apar \u00een partea N-terminal\u0103 a genei CEBPA, ceea\nce duce la producerea unei proteine \u200b\u200bC \/ EBP\u03b1 scurte, izoformei p30, care este\nresponsabil\u0103 pentru men\u021binerea celulelor \u00eentr-o stare imatur\u0103 \u0219i poate declan\u0219a\napari\u021bia leucemiei&#8221;, a afirmat dr. Luisa Schmidt. &nbsp;&nbsp;<\/p>\n\n\n\n<p>Totodat\u0103, oamenii\nde \u0219tiin\u021b\u0103 au observat c\u0103 varianta proteic\u0103 oncogenic\u0103 C \/ EBP\u03b1 p30, care este produs\u0103\n\u00een exces, ca rezultat al muta\u021biei, face uz de mecanisme epigenetice pentru a\ncontrola exprimarea genelor \u00een celulele leucemice. <\/p>\n\n\n\n<p>Surs\u0103: https:\/\/www.sciencedaily.com<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cercet\u0103torii de la Institutul Ludwig Boltzmann din Viena au identificat o nou\u0103 strategie terapeutic\u0103 pentru leucemia mieloid\u0103 acut\u0103 (AML), cea<\/p>\n","protected":false},"author":1,"featured_media":4206,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[101,837,153,64,11,166],"tags":[1855,768,1854,1853],"_links":{"self":[{"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/posts\/4205"}],"collection":[{"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/comments?post=4205"}],"version-history":[{"count":1,"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/posts\/4205\/revisions"}],"predecessor-version":[{"id":4207,"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/posts\/4205\/revisions\/4207"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/media\/4206"}],"wp:attachment":[{"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/media?parent=4205"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/categories?post=4205"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/tags?post=4205"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}