{"id":4183,"date":"2019-05-19T09:19:54","date_gmt":"2019-05-19T06:19:54","guid":{"rendered":"https:\/\/mereusanatosi.ro\/wp\/?p=4183"},"modified":"2019-05-19T09:19:56","modified_gmt":"2019-05-19T06:19:56","slug":"a-fost-descoperita-mutatia-responsabila-de-aparitia-cancerului-la-copii","status":"publish","type":"post","link":"https:\/\/mereusanatosi.ro\/wp\/2019\/05\/19\/a-fost-descoperita-mutatia-responsabila-de-aparitia-cancerului-la-copii\/","title":{"rendered":"A fost descoperit\u0103 muta\u021bia responsabil\u0103 de apari\u021bia cancerului la copii"},"content":{"rendered":"\n<figure class=\"wp-block-image\"><img loading=\"lazy\" width=\"800\" height=\"445\" src=\"https:\/\/mereusanatosi.ro\/wp\/wp-content\/uploads\/2019\/05\/cancer_copii-800x445.jpg\" alt=\"\" class=\"wp-image-4184\" srcset=\"https:\/\/mereusanatosi.ro\/wp\/wp-content\/uploads\/2019\/05\/cancer_copii-800x445.jpg 800w, https:\/\/mereusanatosi.ro\/wp\/wp-content\/uploads\/2019\/05\/cancer_copii-300x167.jpg 300w, https:\/\/mereusanatosi.ro\/wp\/wp-content\/uploads\/2019\/05\/cancer_copii-768x427.jpg 768w, https:\/\/mereusanatosi.ro\/wp\/wp-content\/uploads\/2019\/05\/cancer_copii.jpg 1067w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><figcaption>Surs\u0103 foto: https:\/\/www.winsightgrocerybusiness.com<\/figcaption><\/figure>\n\n\n\n<p>Cercet\u0103torii de la\nUniversitatea din Texas au descoperit c\u0103 tumorile maligne de rhabdoid (un\ncancer pediatric rar), pot fi sensibile la medicamente care blocheaz\u0103\ncapacitatea celulelor canceroase de a elimina anumite proteine. &nbsp;Constat\u0103rile furnizeaz\u0103 o \u021bint\u0103 terapeutic\u0103\nnecesar\u0103 pentru tipurile de cancer cauzate de muta\u021bii \u00een gena SMARCB1. <\/p>\n\n\n\n<p>Pe baza acestor\ndescoperiri, cercet\u0103torii conduc acum un studiu clinic, pentru a investiga\naceast\u0103 abordare \u00een carcinomul renal medular (RMC), un tip de cancer\ncaracterizat, de asemenea, prin muta\u021bii SMARCB1. Tumorile maligne de rhabdoid reprezint\u0103\ncancere pediatrice agresive, care se manifest\u0103, \u00een general, la copii \u00een primul\nan de via\u021b\u0103.<\/p>\n\n\n\n<p>\u201eOp\u021biunile actuale\nde tratament includ chimioterapie cu doze mari \u0219i radia\u021bii, care pot provoca\ndaune neurologice \u0219i cresc riscul de apari\u021bie a cancerelor secundare\u201d, a\nafirmat dr. Giannicola Genovese. <\/p>\n\n\n\n<p>Cercet\u0103torii au analizat\nun model de \u0219oarece cu MRT, pentru a studia biologia bolii \u0219i pentru a\ndescoperi diverse vulnerabilit\u0103\u021bi. Ace\u0219tia au demonstrat c\u0103 SMARCB1 (deficit de\ncelule) este caracterizat de o dereglare de sintez\u0103 de proteine\u200b. Proteinele\nexcesive pot fi toxice pentru celul\u0103, astfel c\u0103 reac\u021biile sunt activate \u00een mod\nnormal pentru a elimina de\u0219eurile de proteine. Oamenii de \u0219tiin\u021b\u0103 au\ndescoperit, de asemenea, c\u0103 celulele canceroase au reu\u0219it s\u0103 &nbsp;supravie\u021buiasc\u0103 prin activitatea de p53, un\nsupresor tumoral care, \u00een mod normal, ac\u021bioneaz\u0103 pentru a bloca dezvoltarea tumorii.\n\u00cen contrast, celulele deficiente SMARCB1 par s\u0103 activeze p53 pentru a\nsupravie\u021bui \u0219i, de fapt, pot beneficia de tratamente de chimioterapie, care\nstimuleaz\u0103 \u00een continuare activitatea p53. <\/p>\n\n\n\n<p>Cercet\u0103torii au\nvizat dou\u0103 mecanisme importante pentru eliminarea de de\u0219euri de proteine,\ncunoscute sub numele de autofagie. S-a constatat c\u0103 blocarea acestora a condus la\nregresia complet\u0103 a tumorii. <\/p>\n\n\n\n<p>Surs\u0103: https:\/\/www.news-medical.net<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cercet\u0103torii de la Universitatea din Texas au descoperit c\u0103 tumorile maligne de rhabdoid (un cancer pediatric rar), pot fi sensibile<\/p>\n","protected":false},"author":1,"featured_media":4184,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[101,155,837,153,64,11],"tags":[1825,1822,1823,1824],"_links":{"self":[{"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/posts\/4183"}],"collection":[{"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/comments?post=4183"}],"version-history":[{"count":1,"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/posts\/4183\/revisions"}],"predecessor-version":[{"id":4185,"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/posts\/4183\/revisions\/4185"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/media\/4184"}],"wp:attachment":[{"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/media?parent=4183"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/categories?post=4183"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/tags?post=4183"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}