{"id":4057,"date":"2019-05-18T19:26:31","date_gmt":"2019-05-18T16:26:31","guid":{"rendered":"https:\/\/mereusanatosi.ro\/wp\/?p=4057"},"modified":"2019-05-18T19:26:34","modified_gmt":"2019-05-18T16:26:34","slug":"secretia-de-mucina-in-cantitati-prea-mari-cauza-unor-boli-grave","status":"publish","type":"post","link":"https:\/\/mereusanatosi.ro\/wp\/2019\/05\/18\/secretia-de-mucina-in-cantitati-prea-mari-cauza-unor-boli-grave\/","title":{"rendered":"Secre\u021bia de mucin\u0103 \u00een cantit\u0103\u021bi prea mari, cauza unor boli grave"},"content":{"rendered":"\n<figure class=\"wp-block-image\"><img loading=\"lazy\" width=\"800\" height=\"445\" src=\"https:\/\/mereusanatosi.ro\/wp\/wp-content\/uploads\/2019\/05\/mucina-800x445.jpg\" alt=\"\" class=\"wp-image-4058\" srcset=\"https:\/\/mereusanatosi.ro\/wp\/wp-content\/uploads\/2019\/05\/mucina-800x445.jpg 800w, https:\/\/mereusanatosi.ro\/wp\/wp-content\/uploads\/2019\/05\/mucina-300x167.jpg 300w, https:\/\/mereusanatosi.ro\/wp\/wp-content\/uploads\/2019\/05\/mucina-768x427.jpg 768w, https:\/\/mereusanatosi.ro\/wp\/wp-content\/uploads\/2019\/05\/mucina.jpg 1067w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><figcaption>Surs\u0103 foto: https:\/\/commons.wikimedia.org<\/figcaption><\/figure>\n\n\n\n<p>\u00cen\nurma unor studii, oamenii de \u0219tiin\u021b\u0103 au descoperit c\u0103 atunci c\u00e2nd sunt expuse\nla un alergen sau agent patogen, celulele produc o cantitate prea mare de mucin\u0103,\n\u00eentr-un timp foarte scurt. Aceast\u0103 secre\u021bie a mucinei este controlat\u0103 de\ncalciu. Cercet\u0103torii de la CRG Gerard Cantero-Recasens au dorit s\u0103 \u00een\u021beleag\u0103 acest\nproces, pentru a putea dezvolta noi proceduri de tratament \u00een cazul bolilor favorizate\nde secre\u021bia de mucin\u0103 \u00een cantit\u0103\u021bi anormale, cum ar fi astmul, boala pulmonar\u0103\nobstructiv\u0103 cronic\u0103, boala Crohn \u0219i cancerul colorectal. <\/p>\n\n\n\n<p>Studiul,\npublicat \u00een Journal of Biological Chemistry dezv\u0103luie dou\u0103 proteine \u200b\u200bnumite\nTRPM4 \u0219i NCX, care lucreaz\u0103 \u00eempreun\u0103 pentru a controla secre\u021bia mucinei, at\u00e2t\n\u00een celulele s\u0103n\u0103toase, c\u00e2t \u0219i \u00een celulele derivate de la pacien\u021bii cu fibroz\u0103\nchistic\u0103. Ei au identificat, de asemenea, o a treia protein\u0103, numit\u0103 KChIP3\ncare sesizeaz\u0103 nivelurile de calciu din celulele s\u0103n\u0103toase pentru a elibera\nmucinele esen\u021biale pentru men\u021binerea grosimii corecte a stratului de mucus din\ncolon. Celulele posed\u0103 mijloace pentru a controla cantitatea de mucin\u0103 pe care\no produc \u00een func\u021bie de nevoile celulare. <\/p>\n\n\n\n<p>Cercet\u0103torii\nau observat c\u0103 celulele produc cantit\u0103\u021bi anormal de mari de mucin\u0103, dac\u0103 sunt\ninfluen\u021bate de prezen\u021ba unui alergen sau agent patogen. Ace\u0219tia au efectuat o\nanaliz\u0103 a genomului, identific\u00e2nd 25 de proteine \u200b\u200bimplicate \u00een secre\u021bia de mucin\u0103\n\u00een celulele cancerului de colon. Echipa a descoperit, de asemenea, un senzor de\ncalciu, KChIP3, \u00een interiorul celulelor care controleaz\u0103 secre\u021bia mucinei. Dac\u0103\nacest senzor intracelular de calciu este pierdut, provoac\u0103 o eliberare masiv\u0103\nde mucin\u0103 din celulele canceroase de colon. <\/p>\n\n\n\n<p>Studiind\ndiferite tipuri de celule, echipa a descoperit c\u0103 celulele folosite pentru\ncontrolul secre\u021biei de mucin\u0103 sunt acelea\u0219i at\u00e2t \u00een \u200b\u200bcolon, c\u00e2t \u0219i \u00een c\u0103ile\nrespiratorii.&nbsp; <\/p>\n\n\n\n<p>Surs\u0103: https:\/\/www.news-medical.net\/news<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00cen urma unor studii, oamenii de \u0219tiin\u021b\u0103 au descoperit c\u0103 atunci c\u00e2nd sunt expuse la un alergen sau agent patogen,<\/p>\n","protected":false},"author":1,"featured_media":4058,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[101,182,153,64,11],"tags":[1686,1239,1253,1687],"_links":{"self":[{"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/posts\/4057"}],"collection":[{"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/comments?post=4057"}],"version-history":[{"count":1,"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/posts\/4057\/revisions"}],"predecessor-version":[{"id":4059,"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/posts\/4057\/revisions\/4059"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/media\/4058"}],"wp:attachment":[{"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/media?parent=4057"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/categories?post=4057"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/tags?post=4057"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}