{"id":2625,"date":"2018-07-19T19:43:06","date_gmt":"2018-07-19T16:43:06","guid":{"rendered":"https:\/\/mereusanatosi.ro\/wp\/?p=2625"},"modified":"2018-07-26T07:59:35","modified_gmt":"2018-07-26T04:59:35","slug":"a-fost-dezvoltat-un-model-care-prezice-rezistenta-la-chimioterapie","status":"publish","type":"post","link":"https:\/\/mereusanatosi.ro\/wp\/2018\/07\/19\/a-fost-dezvoltat-un-model-care-prezice-rezistenta-la-chimioterapie\/","title":{"rendered":"A fost dezvoltat un model care prezice rezisten\u021ba la chimioterapie"},"content":{"rendered":"<figure id=\"attachment_2626\" aria-describedby=\"caption-attachment-2626\" style=\"width: 800px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" class=\"wp-image-2626 size-large\" src=\"https:\/\/mereusanatosi.ro\/wp\/wp-content\/uploads\/2018\/07\/rezisten\u021ba-la-chimioterapie-800x445-1024x569.jpg\" alt=\"Surs\u0103 foto: https:\/\/www.scitecheuropa.eu\" width=\"800\" height=\"445\" \/><figcaption id=\"caption-attachment-2626\" class=\"wp-caption-text\">Surs\u0103 foto: https:\/\/www.scitecheuropa.eu<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<p>Dr. Hossein Tavana \u0219i echipa sa au inventat o metod\u0103 de a grupa culturile 3D de celule canceroase (numite sferoizi) care s\u0103 imite mai bine tumorile din organism, dec\u00e2t culturile 2D utilizate \u00een metodele tradi\u021bionale, pentru a permite testarea medicamentului.<\/p>\n<p>Cre\u0219terea celulelor este un proces puternic reglementat \u00een \u021besuturile s\u0103n\u0103toase. Cu toate acestea, acest proces este dereglat \u00een celulele canceroase, permi\u021b\u00e2ndu-le s\u0103 creasc\u0103 \u00een mod continuu pentru a forma tumori. Aceast\u0103 cre\u0219tere este determinat\u0103 de semnalizarea prin mai multe c\u0103i. Identificarea acestor c\u0103i prezint\u0103 noi obiective atractive pentru tratamentul cu inhibitori moleculari specifici, care sunt mult mai pu\u021bin toxici pentru pacien\u021bi dec\u00e2t medicamentele conven\u021bionale de chimioterapie.<\/p>\n<p>Eforturile recente de a bloca activitatea a dou\u0103 c\u0103i, prin utilizarea simultan\u0103 a doi inhibitori au fost oarecum eficiente \u00eempotriva tumorilor, dar au generat toxicitate excesiv\u0103 la pacien\u021bi \u0219i, ca urmare, studiile clinice au trebuit s\u0103 se opreasc\u0103. Pacien\u021bii cu cancer primesc tratamente \u00een faze multiple, dar cancerul este o boal\u0103 adaptiv\u0103. Pacien\u021bii r\u0103spund bine la medicamente pentru cancer \u00een timpul fazei ini\u021biale de tratament, dar de multe ori dezvolt\u0103 rezisten\u021b\u0103 la acelea\u0219i medicamente mai t\u00e2rziu. Prin urmare, cercet\u0103torii au dezvoltat un model pentru a prezice evolu\u021bia unei astfel de rezisten\u021be. Modelul imit\u0103 modul \u00een care pacien\u021bii primesc chimioterapie, prin tratarea modelelor tumorale cu medicamente pentru cancer. Prin utilizarea analizelor moleculare, oameniii de \u0219tiin\u021b\u0103 vor explora mecanismele specifice pe care celulele le folosesc pentru a se adapta tratamentului.<\/p>\n<p>&nbsp;<\/p>\n<p>Surs\u0103: https:\/\/www.news-medical.net\/news\/20180716\/3D-modeling-of-drug-resistance-could-lead-to-more-effective-cancer-treatment.aspx<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; Dr. Hossein Tavana \u0219i echipa sa au inventat o metod\u0103 de a grupa culturile 3D de celule canceroase (numite<\/p>\n","protected":false},"author":1,"featured_media":2626,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[101,153,11],"tags":[757,759,760,758],"_links":{"self":[{"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/posts\/2625"}],"collection":[{"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/comments?post=2625"}],"version-history":[{"count":2,"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/posts\/2625\/revisions"}],"predecessor-version":[{"id":2628,"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/posts\/2625\/revisions\/2628"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/media\/2626"}],"wp:attachment":[{"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/media?parent=2625"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/categories?post=2625"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mereusanatosi.ro\/wp\/wp-json\/wp\/v2\/tags?post=2625"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}